Journal of Clinical Research and Applied Medicine <p style="user-select: auto;">The Journal of Clinical Research and Applied Medicine <strong style="user-select: auto;">(JCRAM</strong>) ISSN<strong>:</strong> 2583-0562 (Online), is a peer-reviewed, quarterly online journal aiming to communicate high-quality research articles, review articles, case studies, case series in the field of Medical Science (From Basic to Advanced research in all the fields of Medical science).</p> <p style="user-select: auto;"><strong style="user-select: auto;">JCRAM</strong> is open access, peer-reviewed and online journal that will encompass all aspects of basic research/clinical studies related to the field of Medical science. With the advancement of new technologies and the increasing expectation and demand from researchers, we are witnessing an enormous growth in clinical research. The journal seeks to promote research, exchange of scientific information, consideration of regulatory mechanisms that promote innovatory research in the field of Medical science. <strong style="user-select: auto;">JCRAM</strong> provides a platform for the exchange of new scientific information in the most precise and expeditious way to achieve timely dissemination of information and cross-fertilization of ideas. It is published quarterly and available in online versions.</p> <p style="user-select: auto;">The journal is Abstracted and Indexed in: Google Scholar, <a href="">Index Copernicus</a>, <a href="">SCILIT</a>.</p> <p style="user-select: auto;"><strong style="user-select: auto;"><u style="user-select: auto;">Scope of the journal</u></strong></p> <p style="user-select: auto;">Journal of Clinical Research and Applied Medicine (<strong style="user-select: auto;">JCRAM</strong>) aims to help students, researchers and scientists, worldwide to benefit from high-quality peer-reviewed articles and to their high performing works in the entire arena of Medical sciences. <strong style="user-select: auto;">JCRAM</strong> take much care in making your article published without much delay with your kind cooperation and support.</p> <p style="user-select: auto;">Original research papers, review articles, short communications, case studies, case series are welcomed provided they demonstrate new findings of relevance to the field as a whole. All articles will be peer-reviewed and will find a place in the Journal of Clinical Research and Innovation in Medicine (<strong style="user-select: auto;">JCRAM</strong>) based on the merit and innovativeness of the research work. <strong style="user-select: auto;">JCRAM</strong> hopes that Researchers, Research scholars, Academician, Industrialists, etc. would make use of this journal for the development of Medical science.</p> <p style="user-select: auto;"><span style="font-size: 0.875rem;"><strong style="user-select: auto;"><em style="user-select: auto;">Subjects Include</em></strong>:</span></p> <ul style="user-select: auto;"> <li style="user-select: auto;">Anatomy</li> <li style="user-select: auto;">Physiology</li> <li style="user-select: auto;">Biochemistry</li> <li style="user-select: auto;">Pharmacology</li> <li style="user-select: auto;">Pathology</li> <li style="user-select: auto;">Forensic Medicine</li> <li style="user-select: auto;">Microbiology</li> <li style="user-select: auto;">ENT</li> <li style="user-select: auto;">Ophthalmology</li> <li style="user-select: auto;">Preventive &amp; Social Medicine</li> <li style="user-select: auto;">Internal Medicine</li> <li style="user-select: auto;">Surgery</li> <li style="user-select: auto;">Obstetrics &amp; Gynecology</li> <li style="user-select: auto;">Pediatrics</li> <li style="user-select: auto;">Anesthesiology</li> <li style="user-select: auto;">Radiology</li> <li style="user-select: auto;">Skin &amp; VD</li> <li style="user-select: auto;">TB &amp; Chest</li> <li style="user-select: auto;">Psychiatry</li> <li style="user-select: auto;">Dentistry</li> <li style="user-select: auto;">Clinical Epidemiology</li> <li style="user-select: auto;">Biomedical Engineering</li> <li style="user-select: auto;">Orthopaedic</li> <li style="user-select: auto;">Pharmacy</li> <li style="user-select: auto;">Nursing/Paramedical</li> <li style="user-select: auto;">Digital Health</li> </ul> en-US Journal of Clinical Research and Applied Medicine 2583-0562 <p>JCRAM and its contents are licensed under a Creative Commons Attribution-Non Commercial-No Derivs 4.0 License. Permissions beyond the scope of this license may be available with <a href=""></a></p> Impact of Mental Illness (Schizophrenia) on Family <p style="text-align: justify;">Many people are ignorant about the fact that mental illnesses can affect the body. They give serious attention to physical wellness but often ignore the mental health of an individual. For instance, many may be aware of physical diseases or disorders and usually common terms such as cancer, heart attack, diabetes etc., can be heard even from a not-so-erudite person. But only a few of them might be knowing the terms used in mental illnesses like psychosis, dementia, schizophrenia, bipolar disorder etc. Often people put all mental disorders into a single category, labelling the patient or the affected individual as mentally sick or lunatic, though medical science has shown that there are different illnesses, disorders, situations and moods affecting cognitive activity. <strong>Read more . . . </strong></p> Mohammed Yunus Pankaj Kumar Chaudhary Copyright (c) 2022 2022-06-24 2022-06-24 2 1 01 02 10.5530/jcram.2.1.1 Role of Doxycycline in Bleeding Manifestations of Dengue Fever <p style="text-align: justify;">Dengue (pronounced DENgee) fever is a painful, debilitating mosquito-borne disease caused by any one of four closely related dengue viruses. <strong>Aim:</strong> To study effect of doxycycline in bleeding manifestations of dengue fever. <strong>Materials and Methods: </strong>Randomized, double blind, placebo controlled, parallel group study was conducted among 100 seropositive dengue patients, age between 18-60 years (fulfilling inclusion and exclusion criteria) at LLR hospital, Kanpur for Dec 2019 – Oct 2021. These patients were randomized into two groups (50 patients in each). One arm received doxycycline and other was given placebo.<strong> Results</strong>: Patient in case group (on doxycycline) had less bleeding manifestations in comparison to control group (on placebo), only 2% having major bleed as compared to 12% controls, that was statistically significant. But no significant difference seen in terms of minor bleeding. Hemodynamic compromise was more in control group (16%) as compared to treatment group (6%). <strong>Conclusion:</strong> Doxycycline might be having some role in reducing bleeding manifestations in dengue infected patients.</p> Gautam Bajpai Rajendra Kumar Verma Copyright (c) 2022 Journal of Clinical Research and Applied Medicine 2022-06-23 2022-06-23 2 1 03 06 10.5530/jcram.2.1.2 A Prospective Observational Study on Impact of Comorbidities in Patients with COVID-19 Infection <p style="text-align: justify;">A novel human Coronavirus severe acute respiratory syndrome Corona-virus 2 (SARS- Cov-2), pandemic has spread rapidly around the globe morbidity and mortality. Co-existence of Comorbidities with COVID-19 are more likely to develop a more severe cause and progression of the disease. <strong>Objectives:</strong> To asses the impact of Comorbidities in covid-19 infected patients. <strong>Materials and Methods: </strong>The study was carried at kR Hospital, Mysuru, Karnataka from April 2021 to June 2021. A total of 168 patients were enrolled in the study as and exclusion criteria. Patient’s data were collected using data collection forms, Patient /patient take cares interview, treatment chart review. <strong>Results:</strong> Most of the cases were male (69.6%) and in the age group of 40-59 years (39.3%) with a median age of 48 years (IQR – 33.55), One thirty-four patients had at least one comorbidity and most common among them were Hypertension (23.2%) and Diabetes (9.5%), The mortality rate was 11.3% and significantly higher proportion of patients with comorbidities died compared to those with none. <strong>Conclusion:</strong> Presence of comorbidities is associated with a poor outcome and are at a greater risk of dying from COVID-19 when compared to that of patients without Comorbidities.</p> Basvanna P L M K Nirosha Navya L Gopal Krishna B Copyright (c) 2022 2022-06-24 2022-06-24 2 1 07 11 10.5530/jcram.2.1.3 Spontaneous Full Length Fundal Uterine Rupture in Unscarred Uterus at Preterm Gestational Age in Primigravida <p>Uterine rupture is associated with major maternal and fetal morbidity and mortality. Presentation may be varying. Here we present very rare spontaneous uterine rupture in unscarred uterus at preterm gestation without going in labour.</p> Manju Lata Verma Uma Singh Rekha Sachan PL Sankhwar Copyright (c) 2022 Journal of Clinical Research and Applied Medicine 2022-06-24 2022-06-24 2 1 12 14 10.5530/jcram.2.1.4 Hepatitis A Virus Infection Induced Prolonged Cholestasis: A Case Report <p style="text-align: justify;"><strong>Introduction: </strong>Hepatitis A is one of the most common causes of Viral Hepatitis among children. Children have asymptomatic or mild form of disease. Serious manifestation like cholestatic jaundice is very rare in Hepatitis A infection in young children. There have been some reports of manifestations of childhood Hepatitis A occurring in isolation. In this article a young child with Hepatitis A infection who had cholestatic jaundice is reported. The child had flu like symptoms with nausea, vomiting and loss of appetite.<strong> Methods:</strong> Routine investigations along with LFT (Liver function test) and Hepatitis viral markers were carried out which revealed hyperbilirubinemia suggestive of cholestatic jaundice with Hepatitis A positive.<strong> Conclusion:</strong> This case illustrates the importance of clinicians having a high clinical suspicion for cholestatic jaundice in patients of Hepatitis A infection.</p> Virendra Kushwaha Pooja Agrawal Vipul Shukla Copyright (c) 2022 2022-06-24 2022-06-24 2 1 15 18 10.5530/jcram.2.1.5