@article{Bajpai_Verma_2022, title={Role of Doxycycline in Bleeding Manifestations of Dengue Fever}, volume={2}, url={https://jcramonline.com/index.php/jcram/article/view/31}, DOI={10.5530/jcram.2.1.2}, abstractNote={<p style="text-align: justify;">Dengue (pronounced DENgee) fever is a painful, debilitating mosquito-borne disease caused by any one of four closely related dengue viruses. <strong>Aim:</strong> To study effect of doxycycline in bleeding manifestations of dengue fever. <strong>Materials and Methods: </strong>Randomized, double blind, placebo controlled, parallel group study was conducted among 100 seropositive dengue patients, age between 18-60 years (fulfilling inclusion and exclusion criteria) at LLR hospital, Kanpur for Dec 2019 – Oct 2021. These patients were randomized into two groups (50 patients in each). One arm received doxycycline and other was given placebo.<strong> Results</strong>: Patient in case group (on doxycycline) had less bleeding manifestations in comparison to control group (on placebo), only 2% having major bleed as compared to 12% controls, that was statistically significant. But no significant difference seen in terms of minor bleeding. Hemodynamic compromise was more in control group (16%) as compared to treatment group (6%). <strong>Conclusion:</strong> Doxycycline might be having some role in reducing bleeding manifestations in dengue infected patients.</p>}, number={1}, journal={Journal of Clinical Research and Applied Medicine}, author={Bajpai, Gautam and Verma, Rajendra Kumar}, year={2022}, month={Jun.}, pages={03–06} }